CTSZ

Across TCGA patient cohorts, CTSZ mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTSZ-associated genes across cancer lineages are C-Raf, ACC1, and PKC-a. Each is linked with CTSZ in more than 1 cancer types. Because this analysis shows association rather than direction, both CTSZ-to-partner and partner-to-CTSZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by CTSZ-low versus CTSZ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSZ→partner) and Y-score (partner→CTSZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.214	+3.000	.001	.036	3	2
UCEC	ACC1 →	+0.431	+3.013	.010	.018	3	1
UCEC	PKC-a →	+0.386	+2.183	.041	.033	3	1
UCEC	YAP_pS127 →	+0.337	+3.000	.025	.036	3	1
UCEC	Caspase-8 →	-0.253	-2.584	.030	.011	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

C-Raf by CTSZ expression — UCEC

Explore this box plot interactively →