CTSW

Across TCGA patient cohorts, CTSW mutation is significantly associated with the RNA expression of many other genes, with 1,645 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTSW-associated genes across cancer lineages are MIR4769, RN7SL462P, and UBE2V1P4. Each is linked with CTSW in more than 2 cancer types. Because this analysis shows association rather than direction, both CTSW-to-partner and partner-to-CTSW results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4769 grouped by CTSW-low versus CTSW-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSW→partner) and Y-score (partner→CTSW) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR4769 →	+0.714	+7.132	<.001	<.001	3	3
BRCA	RN7SL462P →	+0.153	+7.731	<.001	.009	3	2
CESC	UBE2V1P4 →	+0.138	+5.103	<.001	.008	3	2
COAD	MIR450B →	+0.205	+4.392	<.001	.006	3	2
SKCM	RN7SL517P →	+0.275	+4.875	<.001	.002	3	2
HNSC	RNU1-35P →	+0.443	+5.578	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,645 associations by consensus.

MIR4769 by CTSW expression — HNSC

Explore this box plot interactively →