CTSW

Across TCGA pan-cancer cohorts, CTSW RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CTSW’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CTSW RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CTSW is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

KIRC, LUAD, and COAD are the cancer types where CTSW tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CTSW RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+2.725	<.001	12	view →
LUAD	Male	All	−1.514	<.001	9	view →
COAD	Female	All	−1.328	<.001	9	view →
LUSC	Male	II,III,IV	−2.372	<.001	8	view →
KIRP	Male	III,IV	+1.230	.014	5	view →
READ	All	All	−1.232	.015	2	view →
UCEC	All	All	−0.802	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CTSW–KIRC

Open the KIRC breakdown →