CTSW

Across TCGA cell cohorts, CTSW RNA expression is significantly associated with the go_rna of many other GO terms, with 1,834 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CTSW-associated GO terms across cancer lineages are Regulation of transforming growth factor beta receptor signaling pathway, Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway, and Regulation of focal adhesion assembly. Each is linked with CTSW in more than 8 cancer types. Because this analysis shows association rather than direction, both CTSW-to-partner and partner-to-CTSW results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transforming growth factor beta receptor signaling pathway grouped by CTSW-low versus CTSW-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSW→partner) and Y-score (partner→CTSW) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Regulation of transforming growth factor beta receptor signaling pathway →	+0.043	+0.397	.004	.003	3	9
LUNG_NSCLC_LUAD	Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway →	+0.041	+0.307	.001	.005	3	8
BLOOD_Leukemia	Regulation of focal adhesion assembly →	+0.057	+2.471	<.001	<.001	3	8
BLOOD_Leukemia	Regulation of cell-substrate junction assembly →	+0.057	+2.471	<.001	<.001	3	8
BLOOD_Leukemia	Regulation of cellular response to growth factor stimulus →	+0.036	+2.790	<.001	<.001	3	8
OESOPHAGUS	Regulation of cell-matrix adhesion →	+0.090	+0.184	.002	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,834 associations by consensus.

Regulation of transforming growth factor beta receptor signaling pathway by CTSW expression — CNS

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