CTSW

Across TCGA cell cohorts, CTSW mutation is significantly associated with the RNA expression of many other genes, with 107 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CTSW-associated genes across cancer lineages are SOCS2, AFG1L, and G6PC2. Each is linked with CTSW in more than 1 cancer types. Because this analysis shows association rather than direction, both CTSW-to-partner and partner-to-CTSW results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SOCS2 grouped by CTSW-low versus CTSW-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSW→partner) and Y-score (partner→CTSW) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SOCS2 →	+1.476	+3.212	.005	.006	3	1
LARGE_INTESTINE	AFG1L →	+0.585	+3.212	.002	.006	3	1
LARGE_INTESTINE	G6PC2 →	+0.022	+2.559	.004	.003	3	1
LARGE_INTESTINE	NMD3 →	+0.524	+3.212	.003	.006	3	1
LARGE_INTESTINE	PPP1CC →	+0.452	+3.212	.002	.006	3	1
LARGE_INTESTINE	RPL17 →	+0.794	+3.212	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 107 associations by consensus.

SOCS2 by CTSW expression — LARGE_INTESTINE

Explore this box plot interactively →