CTSLP8

Across TCGA pan-cancer cohorts, CTSLP8 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CTSLP8’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CTSLP8 RNA is repressed in tumor relative to normal tissue. In most cancer types CTSLP8 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

COAD, LUSC, and LUAD are the cancer types where CTSLP8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CTSLP8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	−0.192	<.001	10	view →
LUSC	Female	All	−0.832	<.001	8	view →
LUAD	Male	All	−0.796	<.001	8	view →
KICH	Female	All	−0.515	<.001	8	view →
KIRP	All	All	−0.440	<.001	8	view →
KIRC	Male	All	−0.335	<.001	5	view →
BLCA	Male	IV	−0.612	.004	4	view →
READ	Female	All	−0.306	.013	2	view →
THCA	All	All	+0.019	.011	2	view →
BRCA	All	II,III,IV	+0.009	.042	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CTSLP8–COAD

Open the COAD breakdown →