CTSG

Across TCGA patient cohorts, CTSG mutation is significantly associated with the RNA expression of many other genes, with 1,123 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CTSG-associated genes across cancer lineages are PSMD11, DDX55, and PFN2. Each is linked with CTSG in more than 2 cancer types. Because this analysis shows association rather than direction, both CTSG-to-partner and partner-to-CTSG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMD11 grouped by CTSG-low versus CTSG-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSG→partner) and Y-score (partner→CTSG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PSMD11 →	+0.485	+3.208	.001	.009	3	3
SKCM	DDX55 →	+0.674	+3.372	.001	.004	3	3
SKCM	PFN2 →	+0.957	+3.331	.003	.005	3	3
LUAD	CEBPZ →	+0.654	+3.240	<.001	.008	3	3
LUAD	RNU6-19P →	+0.651	+2.939	<.001	.001	3	3
LUAD	MIR6783 →	+0.337	+2.824	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,123 associations by consensus.

PSMD11 by CTSG expression — SKCM

Explore this box plot interactively →