CTSD

Across TCGA patient cohorts, CTSD mutation is significantly associated with the RNA expression of many other genes, with 1,006 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTSD-associated genes across cancer lineages are RNU6-709P, MTATP6P21, and LINC00380. Each is linked with CTSD in more than 2 cancer types. Because this analysis shows association rather than direction, both CTSD-to-partner and partner-to-CTSD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-709P grouped by CTSD-low versus CTSD-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSD→partner) and Y-score (partner→CTSD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-709P →	+0.286	+5.178	<.001	.002	3	3
UCEC	MTATP6P21 →	+0.213	+2.266	<.001	.001	3	3
BLCA	LINC00380 →	+0.186	+5.311	<.001	.001	3	2
BLCA	TPT1P11 →	+0.058	+3.320	<.001	.008	3	2
CESC	WRBP1 →	+0.221	+4.234	.001	.008	3	2
LUAD	RARRES2P5 →	+0.191	+5.798	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,006 associations by consensus.

RNU6-709P by CTSD expression — HNSC

Explore this box plot interactively →