CTSD

Across TCGA pan-cancer cohorts, CTSD RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CTSD data layer compared with 4 for mutation status.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher CTSD RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CTSD expression acts as an unfavorable survival marker, although some lineages such as DLBC and UVM show a favorable association.

DLBC, LAML, and LGG are the cancer types where CTSD RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Quartile	All	1.000	0.546	.005	49	view →
LAML	DFS	Quartile	All	0.206	0.602	<.001	44	view →
LGG	DFS	Median	All	0.324	0.478	<.001	39	view →
LUSC	OS	Median	All	0.593	0.718	.002	36	view →
OV	OS	Quartile	III,IV	0.249	0.389	.002	36	view →
GBM	OS	Quartile	All	0.321	0.551	<.001	34	view →
UVM	DFS	Median	III,IV	0.806	0.320	<.001	31	view →
KICH	OS	Quartile	II,III,IV	0.886	1.000	.015	27	view →
KIRP	DFS	Tertile	All	0.920	0.773	.002	25	view →
KIRC	DFS	Quartile	II,III,IV	0.656	0.355	.003	21	view →
SCLC	DFS	Quartile	All	0.807	0.443	.002	18	view →
LIHC	OS	Tertile	All	0.707	0.850	.011	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CTSD–DLBC (DFS)

Open the DLBC breakdown →