CTSD

Across TCGA patient cohorts, CTSD mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTSD-associated genes across cancer lineages are HER3, Ku80, and MAPK_pT202_Y204. Each is linked with CTSD in more than 1 cancer types. Because this analysis shows association rather than direction, both CTSD-to-partner and partner-to-CTSD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3 grouped by CTSD-low versus CTSD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSD→partner) and Y-score (partner→CTSD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3 →	+0.430	+2.183	<.001	.033	3	1
UCEC	Ku80 →	+0.240	+1.710	.013	.025	3	1
UCEC	MAPK_pT202_Y204 →	-0.465	-3.321	.016	.010	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.433	-2.321	.019	.034	3	1
UCEC	p62 Lck ligand →	+0.308	+3.169	.021	.018	3	1
UCEC	PCNA →	+0.281	+2.459	.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

HER3 by CTSD expression — UCEC

Explore this box plot interactively →