CTSD

Across TCGA cell cohorts, CTSD RNA expression is significantly associated with the go_rna of many other GO terms, with 6,270 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CTSD-associated GO terms across cancer lineages are Response to topologically incorrect protein, Protein targeting to lysosome involved in chaperone-mediated autophagy, and Viral process. Each is linked with CTSD in more than 14 cancer types. Because this analysis shows association rather than direction, both CTSD-to-partner and partner-to-CTSD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to topologically incorrect protein grouped by CTSD-low versus CTSD-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSD→partner) and Y-score (partner→CTSD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Response to topologically incorrect protein →	+0.085	+1.663	<.001	<.001	3	15
BONE	Protein targeting to lysosome involved in chaperone-mediated autophagy →	+0.212	+1.887	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Viral process →	+0.100	+2.310	.001	<.001	3	14
SOFT_TISSUE	Positive regulation of proteolysis →	+0.113	+1.597	<.001	<.001	3	14
BONE	Regulation of ATF6-mediated unfolded protein response →	+0.119	+1.377	<.001	<.001	3	13
SOFT_TISSUE	Positive regulation of protein localization to membrane →	+0.119	+1.510	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,270 associations by consensus.

Response to topologically incorrect protein by CTSD expression — BONE

Explore this box plot interactively →