CTSD

Across TCGA cell cohorts, CTSD mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CTSD-associated genes across cancer lineages are GUCA2A and KRTAP7-1. Each is linked with CTSD in more than 1 cancer types. Because this analysis shows association rather than direction, both CTSD-to-partner and partner-to-CTSD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA2A grouped by CTSD-low versus CTSD-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSD→partner) and Y-score (partner→CTSD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GUCA2A →	+0.052	+5.969	<.001	.001	3	1
BLOOD_Leukemia	KRTAP7-1 →	+0.095	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

GUCA2A by CTSD expression — BLOOD_Leukemia

Explore this box plot interactively →