CTSC

Across TCGA patient cohorts, CTSC mutation is significantly associated with the RNA expression of many other genes, with 1,979 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTSC-associated genes across cancer lineages are OR4M1, LINC00458, and RN7SL134P. Each is linked with CTSC in more than 2 cancer types. Because this analysis shows association rather than direction, both CTSC-to-partner and partner-to-CTSC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4M1 grouped by CTSC-low versus CTSC-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSC→partner) and Y-score (partner→CTSC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	OR4M1 →	+0.502	+6.918	<.001	<.001	3	3
UCEC	LINC00458 →	+0.188	+1.746	<.001	.004	3	3
UCEC	RN7SL134P →	+0.094	+2.014	.003	.006	3	2
UCEC	SNHG30 →	+0.536	+2.828	<.001	.001	3	2
UCEC	YTHDF3-AS1 →	+0.641	+1.979	<.001	.002	3	2
UCEC	RNA5SP411 →	+1.353	+2.152	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,979 associations by consensus.

OR4M1 by CTSC expression — LUSC

Explore this box plot interactively →