CTSC

Across TCGA pan-cancer cohorts, CTSC RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CTSC’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CTSC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CTSC is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, THCA, and BLCA are the cancer types where CTSC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CTSC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.958	<.001	12	view →
THCA	Male	III,IV	+2.517	<.001	11	view →
BLCA	Male	III,IV	+1.874	<.001	11	view →
KIRP	Female	All	+1.545	<.001	9	view →
STAD	Male	III,IV	+1.866	<.001	8	view →
KICH	All	II,III,IV	−1.645	<.001	8	view →
LIHC	All	II,III,IV	+1.174	<.001	8	view →
UCEC	All	All	+0.825	.001	4	view →
CHOL	Female	All	+4.073	<.001	3	view →
ESCA	All	All	+1.533	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CTSC–HNSC

Open the HNSC breakdown →