CTSC

Across TCGA patient cohorts, CTSC mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTSC-associated genes across cancer lineages are INPP4B, MEK1, and mTOR_pS2448. Each is linked with CTSC in more than 1 cancer types. Because this analysis shows association rather than direction, both CTSC-to-partner and partner-to-CTSC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by CTSC-low versus CTSC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSC→partner) and Y-score (partner→CTSC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.255	-2.459	.035	.018	3	2
UCEC	MEK1 →	+0.560	+2.662	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.139	-1.765	.012	.014	3	2
UCEC	p21 →	+0.148	+2.335	.039	.018	3	2
UCEC	Rab25 →	-0.446	-2.662	<.001	<.001	3	2
UCEC	ATM →	-0.651	-3.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

INPP4B by CTSC expression — UCEC

Explore this box plot interactively →