CTSC

Across TCGA cell cohorts, CTSC mutation is significantly associated with the RNA expression of many other genes, with 1,026 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CTSC-associated genes across cancer lineages are GCAT, CBY1, and JOSD1. Each is linked with CTSC in more than 1 cancer types. Because this analysis shows association rather than direction, both CTSC-to-partner and partner-to-CTSC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCAT grouped by CTSC-low versus CTSC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSC→partner) and Y-score (partner→CTSC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GCAT →	+1.146	+2.502	.002	.005	3	1
LARGE_INTESTINE	CBY1 →	+0.735	+3.482	<.001	<.001	3	1
LARGE_INTESTINE	JOSD1 →	+0.548	+2.502	.002	.005	3	1
LARGE_INTESTINE	MCAT →	+0.684	+3.252	<.001	.002	3	1
LARGE_INTESTINE	POLR3H →	+0.851	+3.321	<.001	.003	3	1
LARGE_INTESTINE	TRMU →	+0.656	+3.321	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,026 associations by consensus.

GCAT by CTSC expression — LARGE_INTESTINE

Explore this box plot interactively →