CTSB

Across TCGA pan-cancer cohorts, CTSB mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CTSB’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CTSB mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CTSB is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

LUAD, PDAC, and LSCC are the cancer types where CTSB tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CTSB mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	+0.785	<.001	9	view →
PDAC	Female	II,III,IV	+0.942	<.001	8	view →
LSCC	Female	All	+0.821	<.001	8	view →
HNSC	Male	II,III,IV	+0.365	<.001	8	view →
CCRCC	Male	All	−0.477	<.001	6	view →
COAD	All	IV	+0.519	.012	2	view →
OV	All	All	+0.447	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CTSB–LUAD

Open the LUAD breakdown →