CTSB

Across TCGA patient cohorts, CTSB mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTSB-associated genes across cancer lineages are MEK1, ASNS, and EGFR_pY1068. Each is linked with CTSB in more than 1 cancer types. Because this analysis shows association rather than direction, both CTSB-to-partner and partner-to-CTSB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CTSB-low versus CTSB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSB→partner) and Y-score (partner→CTSB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.428	+3.459	.007	.005	3	2
UCEC	ASNS →	+0.498	+3.321	.001	.009	3	2
UCEC	EGFR_pY1068 →	-0.258	-2.115	.018	.019	3	1
UCEC	A-Raf_pS299 →	-0.151	-3.321	.003	.010	3	1
UCEC	ERK2 →	+0.191	+2.999	.023	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.122	-2.321	.025	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

MEK1 by CTSB expression — UCEC

Explore this box plot interactively →