CTSB

Across TCGA cell cohorts, CTSB mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CTSB-associated genes across cancer lineages are ELOA3DP, ACTL7A, and PTTG2. Each is linked with CTSB in more than 1 cancer types. Because this analysis shows association rather than direction, both CTSB-to-partner and partner-to-CTSB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOA3DP grouped by CTSB-low versus CTSB-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSB→partner) and Y-score (partner→CTSB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ELOA3DP →	+0.029	+2.688	<.001	.008	3	1
LARGE_INTESTINE	ACTL7A →	+0.020	+3.145	.001	.004	3	1
LARGE_INTESTINE	PTTG2 →	+0.089	+3.497	<.001	.004	3	1
LARGE_INTESTINE	FAM205A →	+0.014	+3.029	.006	.003	2	1
LARGE_INTESTINE	MSH4 →	+0.294	+3.464	<.001	.004	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ELOA3DP by CTSB expression — LARGE_INTESTINE

Explore this box plot interactively →