CTRC

Across TCGA patient cohorts, CTRC mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTRC-associated genes across cancer lineages are ERK2, Annexin-1, and Caspase-8. Each is linked with CTRC in more than 1 cancer types. Because this analysis shows association rather than direction, both CTRC-to-partner and partner-to-CTRC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by CTRC-low versus CTRC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTRC→partner) and Y-score (partner→CTRC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.200	+3.000	.031	.036	3	1
UCEC	Annexin-1 →	+0.539	+2.827	.034	.035	3	1
UCEC	Caspase-8 →	-0.278	-3.295	.022	.009	3	1
UCEC	14-3-3_beta →	-0.109	-2.979	.024	.036	2	1
UCEC	p27_pT198 →	+0.114	+2.459	.027	.020	1	1
UCEC	VHL →	-1.142	-2.459	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ERK2 by CTRC expression — UCEC

Explore this box plot interactively →