CTRC

Across TCGA pan-cancer cohorts, CTRC RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of CTRC’s most consistent transcriptional readouts.

The strongest signal is observed in cholangiocarcinoma (CHOL), where CTRC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CTRC is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

CHOL, KICH, and THCA are the cancer types where CTRC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CTRC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CHOL	Female	All	+0.140	<.001	5	view →
KICH	All	All	−0.028	.003	5	view →
THCA	Female	III,IV	+0.248	.002	4	view →
BLCA	Female	All	−0.096	.033	2	view →
READ	All	All	+0.045	.040	1	view →
COAD	All	All	+0.044	.037	1	view →
LIHC	All	All	+0.024	.038	1	view →
KIRC	Female	All	+0.022	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

CTRC–CHOL

Open the CHOL breakdown →