CTRC

Across TCGA cell cohorts, CTRC mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CTRC-associated genes across cancer lineages are KIR3DL1, TMEM213, and IRX4. Each is linked with CTRC in more than 1 cancer types. Because this analysis shows association rather than direction, both CTRC-to-partner and partner-to-CTRC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIR3DL1 grouped by CTRC-low versus CTRC-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTRC→partner) and Y-score (partner→CTRC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KIR3DL1 →	+0.026	+3.691	<.001	.002	3	1
BLOOD_Leukemia	TMEM213 →	+0.097	+4.169	<.001	.003	3	1
BLOOD_Leukemia	IRX4 →	+0.146	+3.847	<.001	.004	2	1
BLOOD_Leukemia	EFNA2 →	+0.500	+3.643	<.001	.006	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

KIR3DL1 by CTRC expression — BLOOD_Leukemia

Explore this box plot interactively →