CTRC

Across TCGA cell cohorts, CTRC mutation is significantly associated with the mutation status of many other genes, with 853 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CTRC-associated genes across cancer lineages are GRIK2, NAV2, and B4GALNT2. Each is linked with CTRC in more than 1 cancer types. Because this analysis shows association rather than direction, both CTRC-to-partner and partner-to-CTRC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRIK2 grouped by CTRC-low versus CTRC-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTRC→partner) and Y-score (partner→CTRC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GRIK2 →	+4.502	+5.066	.007	.007	1	2
BLOOD_Leukemia	NAV2 →	+2.202	+3.442	.002	.002	1	2
SOFT_TISSUE	B4GALNT2 →	+5.502	+5.502	.003	.003	1	2
BLOOD_Leukemia	CCDC88B →	+2.465	+3.156	.005	.005	1	2
SOFT_TISSUE	CDC42BPG →	+4.502	+5.066	.007	.007	1	2
BLOOD_Leukemia	FIBP →	+4.465	+4.465	<.001	<.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 853 associations by consensus.

GRIK2 by CTRC expression — SOFT_TISSUE

Explore this box plot interactively →