CTPS1

Across TCGA patient cohorts, CTPS1 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,873 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CTPS1-associated proteins across cancer lineages are SMC2, SMC4, and NCAPD2. Each is linked with CTPS1 in more than 8 cancer types. Because this analysis shows association rather than direction, both CTPS1-to-partner and partner-to-CTPS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CTPS1 versus SMC2 in GBM, with a Pearson correlation of 0.70.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CTPS1→partner) and Y-score (partner→CTPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC2 →	+0.657	+0.524	<.001	<.001	3	9
GBM	SMC4 →	+0.606	+0.527	<.001	<.001	3	9
BRCA	NCAPD2 →	+0.639	+0.772	<.001	<.001	3	9
BRCA	NCAPG →	+0.614	+0.764	<.001	<.001	3	9
OV	CTPS1_S562 →	+0.673	+0.619	<.001	<.001	3	9
GBM	NASP →	+0.673	+0.589	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,873 associations by consensus.

CTPS1 vs SMC2 — GBM

Explore this scatter interactively →