CTPS1

Across TCGA cell cohorts, CTPS1 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CTPS1-associated genes across cancer lineages are GHR, GALR3, and ASTN1. Each is linked with CTPS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTPS1-to-partner and partner-to-CTPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHR grouped by CTPS1-low versus CTPS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTPS1→partner) and Y-score (partner→CTPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GHR →	+0.447	+3.667	.006	.003	3	1
LARGE_INTESTINE	GALR3 →	+0.108	+3.602	<.001	.005	3	1
LARGE_INTESTINE	ASTN1 →	+0.482	+3.825	.001	.006	3	1
LARGE_INTESTINE	TUB →	+1.495	+3.527	<.001	.002	3	1
LARGE_INTESTINE	GKN1 →	+0.052	+3.247	<.001	.001	3	1
LARGE_INTESTINE	GLIS1 →	+0.278	+3.991	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

GHR by CTPS1 expression — LARGE_INTESTINE

Explore this box plot interactively →