CTNND2

Across TCGA patient cohorts, CTNND2 mutation is significantly associated with the RNA expression of many other genes, with 8,723 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTNND2-associated genes across cancer lineages are RITA1, PHF5A, and PDCD2L. Each is linked with CTNND2 in more than 6 cancer types. Because this analysis shows association rather than direction, both CTNND2-to-partner and partner-to-CTNND2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RITA1 grouped by CTNND2-low versus CTNND2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTNND2→partner) and Y-score (partner→CTNND2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RITA1 →	+0.340	+3.636	<.001	.001	3	7
STAD	PHF5A →	+0.367	+1.942	.001	.002	3	6
LUAD	PDCD2L →	+0.408	+1.584	<.001	.007	3	6
STAD	SUPV3L1 →	+0.327	+3.919	.004	<.001	3	6
UCEC	PGAM5 →	+0.430	+2.050	<.001	<.001	3	6
LUAD	CDKN3 →	+0.780	+2.584	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,723 associations by consensus.

RITA1 by CTNND2 expression — HNSC

Explore this box plot interactively →