CTNNBL1

Across TCGA pan-cancer cohorts, CTNNBL1 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CTNNBL1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CTNNBL1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CTNNBL1 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

HNSC, COAD, and LSCC are the cancer types where CTNNBL1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CTNNBL1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.511	<.001	11	view →
COAD	Male	III,IV	+0.728	<.001	10	view →
LSCC	Male	All	+0.446	<.001	9	view →
LUAD	Male	All	+0.238	<.001	8	view →
OV	All	All	+0.371	.005	2	view →
CCRCC	All	III,IV	+0.076	.006	2	view →
PDAC	Male	IV	−0.255	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CTNNBL1–HNSC

Open the HNSC breakdown →