CTNNBL1

Across TCGA pan-cancer cohorts, CTNNBL1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated CTNNBL1 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CTNNBL1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CTNNBL1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

KIRC, BLCA, and SCLC are the cancer types where CTNNBL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.756	0.502	<.001	60	view →
BLCA	OS	Tertile	All	0.686	0.803	.002	49	view →
SCLC	OS	Tertile	III,IV	0.725	0.257	.001	49	view →
KICH	DFS	Median	III,IV	0.280	0.910	.001	38	view →
HNSC	OS	Tertile	All	0.689	0.810	.002	33	view →
MESO	DFS	Quartile	All	0.251	0.460	.010	30	view →
BRCA	DFS	Median	IV	0.952	0.530	.004	26	view →
UCEC	DFS	Median	All	0.577	0.712	.002	24	view →
LIHC	DFS	Median	All	0.268	0.563	<.001	23	view →
KIRP	DFS	Quartile	All	0.830	0.954	.006	23	view →
COAD	DFS	Quartile	All	0.563	0.815	.001	22	view →
OV	OS	Quartile	All	0.747	0.883	.001	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

CTNNBL1–KIRC (DFS)

Open the KIRC breakdown →