CTNNBL1

Across TCGA patient cohorts, CTNNBL1 mutation is significantly associated with the RNA expression of many other genes, with 2,648 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTNNBL1-associated genes across cancer lineages are TUBGCP5, PHBP13, and ITCH-AS1. Each is linked with CTNNBL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTNNBL1-to-partner and partner-to-CTNNBL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBGCP5 grouped by CTNNBL1-low versus CTNNBL1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTNNBL1→partner) and Y-score (partner→CTNNBL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TUBGCP5 →	+0.555	+3.465	.009	.003	3	2
SKCM	PHBP13 →	+0.478	+3.491	<.001	.002	3	2
SKCM	ITCH-AS1 →	+0.084	+2.461	.004	.006	3	2
SKCM	RNU1-80P →	+0.110	+3.385	<.001	.004	3	2
UCEC	LIN7C →	+0.397	+1.856	.007	.004	3	2
UCEC	DLAT →	+0.429	+2.202	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,648 associations by consensus.

TUBGCP5 by CTNNBL1 expression — SKCM

Explore this box plot interactively →