CTNNBL1

Across TCGA cell cohorts, CTNNBL1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CTNNBL1-associated genes across cancer lineages are XAGE5, OR2D3, and OR2A25. Each is linked with CTNNBL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTNNBL1-to-partner and partner-to-CTNNBL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XAGE5 grouped by CTNNBL1-low versus CTNNBL1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTNNBL1→partner) and Y-score (partner→CTNNBL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	XAGE5 →	+0.255	+5.196	<.001	.005	3	1
SKIN	OR2D3 →	+0.046	+4.095	<.001	.009	3	1
SKIN	OR2A25 →	+0.053	+4.467	<.001	.004	3	1
LARGE_INTESTINE	ACER1 →	+0.127	+3.453	<.001	.009	3	1
LARGE_INTESTINE	WDR87 →	+0.030	+4.353	<.001	.001	3	1
LARGE_INTESTINE	FAM205A →	+0.026	+3.614	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

XAGE5 by CTNNBL1 expression — OVARY

Explore this box plot interactively →