CTNNB1

Across TCGA patient cohorts, CTNNB1 mutation is significantly associated with the RNA expression of many other genes, with 12,097 significant associations in total. LIHC shows the largest number of these associations.

The most reproducible CTNNB1-associated genes across cancer lineages are LINC02563, DEFA5, and ZNRF3. Each is linked with CTNNB1 in more than 7 cancer types. Because this analysis shows association rather than direction, both CTNNB1-to-partner and partner-to-CTNNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02563 grouped by CTNNB1-low versus CTNNB1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTNNB1→partner) and Y-score (partner→CTNNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC02563 →	+0.969	+4.927	<.001	<.001	3	8
CESC	DEFA5 →	+4.942	+4.671	<.001	<.001	3	6
UCEC	ZNRF3 →	+0.190	+0.934	<.001	<.001	3	6
BLCA	FGF3 →	+4.527	+3.618	<.001	<.001	3	6
BLCA	LINC01780 →	+0.864	+3.206	<.001	.002	3	6
UCEC	CST1 →	+3.420	+1.455	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,097 associations by consensus.

LINC02563 by CTNNB1 expression — CESC

Explore this box plot interactively →