CTNNAL1

Across TCGA patient cohorts, CTNNAL1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTNNAL1-associated genes across cancer lineages are TFRC, ASNS, and ATM. Each is linked with CTNNAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTNNAL1-to-partner and partner-to-CTNNAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by CTNNAL1-low versus CTNNAL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTNNAL1→partner) and Y-score (partner→CTNNAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.375	+3.321	.038	.009	3	2
UCEC	ASNS →	+0.369	+1.678	.002	.021	3	2
UCEC	ATM →	-0.618	-2.502	<.001	.001	3	2
UCEC	4E-BP1_pS65 →	-0.159	-2.459	.016	.018	3	2
UCEC	EGFR_pY1068 →	-0.188	-1.807	.027	.004	3	1
UCEC	eIF4G →	+0.262	+3.169	.013	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

TFRC by CTNNAL1 expression — UCEC

Explore this box plot interactively →