CTNNAL1

Across TCGA pan-cancer cohorts, CTNNAL1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CTNNAL1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CTNNAL1 RNA is repressed in tumor relative to normal tissue. In most cancer types CTNNAL1 is over-expressed in tumor, although a few such as KIRC and BLCA show the opposite, repressed pattern.

KIRC, BLCA, and LUSC are the cancer types where CTNNAL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CTNNAL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.656	<.001	12	view →
BLCA	Male	All	−1.513	<.001	8	view →
LUSC	Female	All	−1.388	<.001	8	view →
HNSC	All	III,IV	+1.230	<.001	8	view →
LUAD	Female	III,IV	−2.123	<.001	7	view →
LIHC	All	II,III,IV	+0.824	<.001	7	view →
BRCA	Female	All	−1.037	<.001	6	view →
KICH	All	All	−1.074	<.001	5	view →
UCEC	All	All	−1.197	<.001	4	view →
COAD	All	All	+0.459	.007	3	view →
KIRP	Male	All	−1.188	<.001	2	view →
CHOL	All	II,III,IV	+0.875	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CTNNAL1–KIRC

Open the KIRC breakdown →