CTNNAL1

Across TCGA cell cohorts, CTNNAL1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CTNNAL1-associated genes across cancer lineages are IGSF21, REG1B, and GAGE12D. Each is linked with CTNNAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTNNAL1-to-partner and partner-to-CTNNAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGSF21 grouped by CTNNAL1-low versus CTNNAL1-high in LIVER.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTNNAL1→partner) and Y-score (partner→CTNNAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	IGSF21 →	+0.041	+3.977	.001	.006	3	1
LARGE_INTESTINE	REG1B →	+3.348	+3.196	<.001	.007	3	1
SKIN	GAGE12D →	+3.388	+4.977	<.001	.007	3	1
CNS	SPATA31D3 →	+0.013	+6.357	<.001	<.001	3	1
LARGE_INTESTINE	RXFP1 →	+0.200	+3.453	<.001	.009	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

IGSF21 by CTNNAL1 expression — LIVER

Explore this box plot interactively →