Across TCGA patient cohorts, CTNNA3 mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTNNA3-associated genes across cancer lineages are Caspase-7-cleavedD198, p38-MAPK_pT180_Y182, and STAT3_pY705. Each is linked with CTNNA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CTNNA3-to-partner and partner-to-CTNNA3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTNNA3→partner) and Y-score (partner→CTNNA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.988	+3.186	.005	.009	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.411	-1.584	.003	.017	3	3
UCEC	STAT3_pY705 →	-0.419	-2.807	<.001	<.001	3	3
STAD	FASN →	+0.470	+2.823	.016	.034	2	3
STAD	FOXO3a_pS318_S321 →	-0.233	-3.300	.006	.010	3	2
STAD	Src_pY527 →	-0.868	-3.000	<.001	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

Exploration

CTNNA3 survival (RNA) · tumor vs normal (RNA) · all CTNNA3 data types