CTDSPL

Across TCGA patient cohorts, CTDSPL mutation is significantly associated with the RNA expression of many other genes, with 1,039 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTDSPL-associated genes across cancer lineages are RN7SL248P, RNU6-1126P, and MIR6859-3. Each is linked with CTDSPL in more than 2 cancer types. Because this analysis shows association rather than direction, both CTDSPL-to-partner and partner-to-CTDSPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by CTDSPL-low versus CTDSPL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTDSPL→partner) and Y-score (partner→CTDSPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.057	+3.078	<.001	.001	3	3
SKCM	RNU6-1126P →	+0.313	+7.816	.002	.008	3	2
BRCA	MIR6859-3 →	+0.555	+6.133	<.001	.001	3	1
UCEC	LIN7C →	+0.533	+3.043	<.001	<.001	3	1
UCEC	ZNF215 →	+0.476	+2.439	.001	.001	3	1
UCEC	COX15 →	+0.416	+2.275	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,039 associations by consensus.

RN7SL248P by CTDSPL expression — UCEC

Explore this box plot interactively →