CTBP1

Across TCGA pan-cancer cohorts, CTBP1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of CTBP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CTBP1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CTBP1 is over-expressed in tumor, although a few such as HNSC and LSCC show the opposite, repressed pattern.

HNSC, LSCC, and PDAC are the cancer types where CTBP1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CTBP1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	−0.283	<.001	11	view →
LSCC	Male	III,IV	−0.232	<.001	7	view →
PDAC	Male	All	+0.333	.004	3	view →
LUAD	Female	All	+0.120	<.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

CTBP1–HNSC

Open the HNSC breakdown →