CTBP1

Across TCGA patient cohorts, CTBP1 mutation is significantly associated with the RNA expression of many other genes, with 3,227 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTBP1-associated genes across cancer lineages are ACBD5, GOT1, and IER3IP1. Each is linked with CTBP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CTBP1-to-partner and partner-to-CTBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACBD5 grouped by CTBP1-low versus CTBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTBP1→partner) and Y-score (partner→CTBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACBD5 →	+0.428	+2.115	.004	<.001	3	3
COAD	GOT1 →	+0.423	+3.183	.005	.009	3	3
COAD	IER3IP1 →	+0.585	+3.556	<.001	.002	3	3
UCEC	RNF138 →	+0.452	+1.836	.006	.001	3	3
UCEC	MRPL50 →	+0.410	+2.601	.001	<.001	3	3
UCEC	NUSAP1 →	+0.623	+2.332	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,227 associations by consensus.

ACBD5 by CTBP1 expression — UCEC

Explore this box plot interactively →