CT55

Across TCGA patient cohorts, CT55 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CT55-associated genes across cancer lineages are p62 Lck ligand, 14-3-3_beta, and ERK2. Each is linked with CT55 in more than 1 cancer types. Because this analysis shows association rather than direction, both CT55-to-partner and partner-to-CT55 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CT55-low versus CT55-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CT55→partner) and Y-score (partner→CT55) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.308	+2.331	.042	.019	3	2
UCEC	14-3-3_beta →	-0.156	-3.295	<.001	.009	3	1
UCEC	ERK2 →	+0.236	+2.999	.008	.035	3	1
UCEC	FoxM1 →	+0.297	+2.817	.013	.036	3	1
UCEC	JNK2 →	+0.276	+2.817	.002	.036	3	1
UCEC	Ku80 →	+0.321	+2.598	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

p62 Lck ligand by CT55 expression — UCEC

Explore this box plot interactively →