CSTF2T

Across TCGA patient cohorts, CSTF2T mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSTF2T-associated genes across cancer lineages are ACC1, PCNA, and Rad50. Each is linked with CSTF2T in more than 1 cancer types. Because this analysis shows association rather than direction, both CSTF2T-to-partner and partner-to-CSTF2T results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by CSTF2T-low versus CSTF2T-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSTF2T→partner) and Y-score (partner→CSTF2T) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.344	+1.440	.006	.024	3	2
UCEC	PCNA →	+0.197	+1.440	.008	.024	3	2
UCEC	Rad50 →	-0.208	-1.736	.013	.007	3	2
UCEC	ATM →	-0.440	-2.687	.005	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.785	+2.242	<.001	.005	3	2
UCEC	4E-BP1 →	+0.321	+3.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

ACC1 by CSTF2T expression — UCEC

Explore this box plot interactively →