CSTF2T

Across TCGA pan-cancer cohorts, CSTF2T RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CSTF2T’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CSTF2T RNA is repressed in tumor relative to normal tissue. In most cancer types CSTF2T is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and KICH are the cancer types where CSTF2T tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CSTF2T RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.742	<.001	10	view →
LIHC	Female	III,IV	+0.875	<.001	9	view →
KICH	Female	All	−1.386	<.001	8	view →
CHOL	All	All	+1.633	<.001	5	view →
HNSC	All	All	+0.336	.003	5	view →
BLCA	All	IV	−1.028	.022	4	view →
STAD	All	II,III,IV	+0.511	.015	4	view →
KIRC	Male	II,III,IV	−0.387	.003	4	view →
READ	All	III,IV	+0.575	.016	2	view →
UCEC	All	All	−0.476	.029	2	view →
KIRP	All	All	−0.274	.020	2	view →
LUSC	All	All	+0.199	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CSTF2T–THCA

Open the THCA breakdown →