CSTB

Across TCGA patient cohorts, CSTB mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSTB-associated genes across cancer lineages are RNA5SP166, RNU4-20P, and MIR548AZ. Each is linked with CSTB in more than 1 cancer types. Because this analysis shows association rather than direction, both CSTB-to-partner and partner-to-CSTB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP166 grouped by CSTB-low versus CSTB-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSTB→partner) and Y-score (partner→CSTB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP166 →	+0.298	+7.954	<.001	.008	3	1
HNSC	RNU4-20P →	+0.379	+7.954	<.001	.008	3	1
HNSC	MIR548AZ →	+0.313	+7.954	<.001	.008	3	1
UCEC	MIR4504 →	+0.536	+4.551	.001	.009	3	1
UCEC	RN7SKP107 →	+0.370	+5.226	<.001	.003	3	1
UCEC	RNA5SP205 →	+0.797	+4.852	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

RNA5SP166 by CSTB expression — HNSC

Explore this box plot interactively →