CST5

Across TCGA cell cohorts, CST5 RNA expression is significantly associated with the go_rna of many other GO terms, with 593 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CST5-associated GO terms across cancer lineages are Positive regulation of protein maturation, Calcium ion transmembrane import into cytosol, and Positive regulation of protein processing. Each is linked with CST5 in more than 4 cancer types. Because this analysis shows association rather than direction, both CST5-to-partner and partner-to-CST5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein maturation grouped by CST5-low versus CST5-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CST5→partner) and Y-score (partner→CST5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of protein maturation →	+0.157	+1.040	<.001	.003	3	5
LUNG_NSCLC_LUAD	Calcium ion transmembrane import into cytosol →	-0.045	-0.496	<.001	.003	3	5
PANCREAS	Positive regulation of protein processing →	+0.148	+1.013	<.001	.004	3	4
PANCREAS	Maintenance of unfolded protein →	+0.095	+1.050	<.001	.007	3	4
PANCREAS	IMP metabolic process →	-0.102	-1.081	<.001	.005	3	4
PANCREAS	Plasma membrane organization →	+0.074	+1.167	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 593 associations by consensus.

Positive regulation of protein maturation by CST5 expression — PANCREAS

Explore this box plot interactively →