CSN3

Across TCGA patient cohorts, CSN3 mutation is significantly associated with the RNA expression of many other genes, with 474 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSN3-associated genes across cancer lineages are FRG2, RNA5SP432, and MTHFD2P5. Each is linked with CSN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSN3-to-partner and partner-to-CSN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FRG2 grouped by CSN3-low versus CSN3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSN3→partner) and Y-score (partner→CSN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FRG2 →	+0.045	+5.283	.006	.006	3	2
LUAD	RNA5SP432 →	+0.427	+6.473	<.001	<.001	3	2
LUAD	MTHFD2P5 →	+0.124	+4.722	<.001	.003	3	2
LUAD	RPS20P25 →	+0.081	+4.712	<.001	.007	3	2
LUAD	RNU6-299P →	+0.264	+4.631	.009	.008	3	2
LUAD	CYP3A137P →	+0.370	+6.599	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 474 associations by consensus.

FRG2 by CSN3 expression — COAD

Explore this box plot interactively →