CSN3

Across TCGA pan-cancer cohorts, CSN3 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated CSN3 data layer compared with 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CSN3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CSN3 expression acts as an unfavorable survival marker, although some lineages such as STAD and BRCA show a favorable association.

UCEC, MESO, and STAD are the cancer types where CSN3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.346	0.717	<.001	102	view →
MESO	DFS	Quartile	IV	0.114	0.453	.008	34	view →
STAD	DFS	Median	IV	0.727	0.126	.002	33	view →
BRCA	OS	Median	All	0.651	0.527	.004	30	view →
LUAD	OS	Tertile	All	0.798	0.667	.019	24	view →
SKCM	DFS	Quartile	III,IV	0.883	0.569	.003	23	view →
LGG	OS	Tertile	All	0.206	0.528	.003	21	view →
UVM	OS	Tertile	III,IV	0.220	0.872	.025	18	view →
CESC	OS	Tertile	IV	0.094	0.450	.042	18	view →
LIHC	DFS	Tertile	All	0.342	0.473	.036	16	view →
KICH	OS	Quartile	III,IV	0.125	0.691	<.001	12	view →
LUSC	DFS	Quartile	II,III,IV	0.709	0.560	.028	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

CSN3–UCEC (OS)

Open the UCEC breakdown →