CSN3

Across TCGA patient cohorts, CSN3 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSN3-associated genes across cancer lineages are ER-alpha, JNK2, and TFRC. Each is linked with CSN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSN3-to-partner and partner-to-CSN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha grouped by CSN3-low versus CSN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSN3→partner) and Y-score (partner→CSN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha →	+0.860	+2.820	.045	.035	3	1
UCEC	JNK2 →	+0.259	+2.834	.012	.034	3	1
UCEC	TFRC →	+0.709	+3.321	.010	.010	3	1
UCEC	TIGAR →	+0.173	+2.196	.030	.034	3	1
UCEC	Caspase-8 →	-0.309	-3.321	.018	.010	2	1
UCEC	53BP1 →	+0.416	+3.321	.020	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ER-alpha by CSN3 expression — UCEC

Explore this box plot interactively →