CSN1S1

Across TCGA patient cohorts, CSN1S1 mutation is significantly associated with the RNA expression of many other genes, with 258 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSN1S1-associated genes across cancer lineages are MIR4666B, OR7E8P, and RNA5SP418. Each is linked with CSN1S1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSN1S1-to-partner and partner-to-CSN1S1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4666B grouped by CSN1S1-low versus CSN1S1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSN1S1→partner) and Y-score (partner→CSN1S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR4666B →	+0.690	+7.731	<.001	.009	3	2
LUAD	OR7E8P →	+0.062	+5.343	<.001	.006	3	2
UCEC	RNA5SP418 →	+0.739	+2.377	<.001	.008	3	2
UCEC	BCAR1P2 →	+0.090	+3.152	.007	<.001	3	2
UCEC	MIR7702 →	+0.309	+4.738	<.001	.002	3	2
SKCM	RN7SL299P →	+0.082	+4.469	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 258 associations by consensus.

MIR4666B by CSN1S1 expression — BRCA

Explore this box plot interactively →