CSN1S1

Across TCGA pan-cancer cohorts, CSN1S1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of CSN1S1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where CSN1S1 RNA is repressed in tumor relative to normal tissue. In most cancer types CSN1S1 is over-expressed in tumor, although a few such as BRCA and HNSC show the opposite, repressed pattern.

BRCA, HNSC, and ESCA are the cancer types where CSN1S1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CSN1S1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	All	−2.257	<.001	6	view →
HNSC	All	All	−0.038	.016	4	view →
ESCA	All	II,III,IV	+0.135	.001	3	view →
THCA	All	All	−0.033	.005	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

CSN1S1–BRCA

Open the BRCA breakdown →