CSN1S1

Across TCGA patient cohorts, CSN1S1 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSN1S1-associated genes across cancer lineages are Notch1, ATM, and eIF4E. Each is linked with CSN1S1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSN1S1-to-partner and partner-to-CSN1S1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CSN1S1-low versus CSN1S1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSN1S1→partner) and Y-score (partner→CSN1S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.163	+2.817	.027	.036	3	1
UCEC	ATM →	-0.613	-3.321	.009	.010	3	1
UCEC	eIF4E →	+0.235	+3.321	.033	.010	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Notch1 by CSN1S1 expression — UCEC

Explore this box plot interactively →