CSN1S1

Across TCGA cell cohorts, CSN1S1 mutation is significantly associated with the drug of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CSN1S1-associated genes across cancer lineages are ML323, Sinularin, and AZD8931. Each is linked with CSN1S1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSN1S1-to-partner and partner-to-CSN1S1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ML323 grouped by CSN1S1-low versus CSN1S1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSN1S1→partner) and Y-score (partner→CSN1S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ML323 →	+0.358	+2.893	.037	.034	3	1
LARGE_INTESTINE	Sinularin →	+0.392	+2.777	.012	.038	3	1
LARGE_INTESTINE	AZD8931 →	+0.849	+2.649	.002	.046	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

ML323 by CSN1S1 expression — LARGE_INTESTINE

Explore this box plot interactively →